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DU 145 was derived in 1975 from a brain lesion in a 69 year-old man with metastatic carcinoma of the prostate and a three year history of lymphocytic leukemia. They are epithelial-like adherent cells growing as monolayers. The DU-145 line is not measurably hormone sensitive. It is only weakly positive for acid phosphatase and isolated cells form colonies in soft agar. Analyses of the cell line has revealed microvilli, tonofilaments and desmosomes. DU-145 do not express prostate antigen but do express functional receptor activator of NFkappaB and androgen receptor. The DU-145 cell line is mostly used in laboratory situations to study the way prostate cancer cells grow. It has been shown glucosamine suppresses proliferation of DU-145.
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